bdhA

bdhA
168

acetoine/ butanediol dehydrogenase

Locus
BSU_06240
Molecular weight
37.19 kDa
Isoelectric point
4.8
Protein length
346 aaSequenceBlast
Gene length
1041 bpSequenceBlast
Function
overflow metabolism, fermentation
Product
acetoine/ butanediol dehydrogenase
Essential
no
E.C.
1.1.1.76
Synonyms
bdhA, ydjL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1063 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
677,911 678,951
The protein
Catalyzed reaction/ biological activity
formation of butanediol from acetoin PubMed
(R,R)-butane-2,3-diol + NAD+ --> (R)-acetoin + H+ + NADH (according to UniProt)
Protein family
zinc-containing alcohol dehydrogenase family (according to UniProt)
Cofactors
NAD+ (according to UniProt)
Structure
6IE0 (PDB)
O34788 (AlphaFold)
Modification
phosphorylated on Arg-13 PubMed
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
bdhA
Description
PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
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bdhA

2025-03-16 16:19:47

Jstuelk

88

db038c4399da9190e64195a4a2f1acef5062de1a

AD4F86B3F3FD5084F3C02020684E1A61FE1F105B

Biological materials
Mutant
MGNA-C219 (ydjL::erm), available at the NBRP B. subtilis, Japan
BKE06240 (bdhA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGGATTACCACTCCTATA, downstream forward: _UP4_TAATTTGAAACCAAAAAGAA
BKK06240 (bdhA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGGATTACCACTCCTATA, downstream forward: _UP4_TAATTTGAAACCAAAAAGAA
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jrg Stlke's lab
References
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Time of last update: 2025-04-05 19:25:33

Author of last update: Jstuelk