SalA

• Description: negative regulator of scoC expression
  
  

Gene name	salA
Synonyms	ybaL
Essential	no
Product	MRP family regulator
Function	control of alkaline protease expression
Gene expression levels in SubtiExpress: salA
MW, pI	38 kDa, 5.23
Gene length, protein length	1056 bp, 352 aa
Immediate neighbours	cwlD, gerD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, transition state regulators

This gene is a member of the following regulons

SalA regulon

The SalA regulon:

• salA, scoC

The gene

Basic information

• Locus tag: BSU01540

Phenotypes of a mutant

increased expression of aprE (due to loss of repression of scoC expression)

Database entries

• BsubCyc: BSU01540

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: negative regulation of scoC expression

• Protein family: Mrp/NBP35 ATP-binding proteins family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU01540

• Structure:

• UniProt: P50863

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: salA PubMed

• Sigma factor:

• Regulation: negative autoregulation

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 841 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 3168 PubMed

Biological materials

• Mutant:
  • 1A919 ( salA::erm), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Mitsuo Ogura, Atsushi Matsuzawa, Hirofumi Yoshikawa, Teruo Tanaka
Bacillus subtilis SalA (YbaL) negatively regulates expression of scoC, which encodes the repressor for the alkaline exoprotease gene, aprE.
J Bacteriol: 2004, 186(10);3056-64
[PubMed:15126467] [WorldCat.org] [DOI] (P p)