YugJ

• Description: similar to NADH-dependent butanol dehydrogenase
  
  

Gene name	yugJ
Synonyms
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: yugJ
MW, pI	42 kDa, 5.221
Gene length, protein length	1161 bp, 387 aa
Immediate neighbours	yugK, yuzA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

Spx regulon

The gene

Basic information

• Locus tag: BSU31370

Database entries

• BsubCyc: BSU31370

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: iron-containing alcohol dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): YugK

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU31370

• Structure:

• UniProt: O05239

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yugJ PubMed

• Expression browser: yugJ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • Spx: transcription activation PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 1310 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 1788 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Laura R Jarboe
YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals.
Appl Microbiol Biotechnol: 2011, 89(2);249-57
[PubMed:20924577] [WorldCat.org] [DOI] (I p)

Original publications

Bauke Oudega, Gregory Koningstein, Luísa Rodrigues, Maria de Sales Ramon, Helmut Hilbert, Andreas Düsterhöft, Thomas M Pohl, Thomas Weitzenegger
Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).
Microbiology (Reading): 1997, 143 ( Pt 8);2769-2774
[PubMed:9274030] [WorldCat.org] [DOI] (P p)

The corresponding protein in E. coli

Changhan Lee, Insook Kim, Junghoon Lee, Kang-Lok Lee, Bumchan Min, Chankyu Park
Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.
J Bacteriol: 2010, 192(16);4205-14
[PubMed:20543070] [WorldCat.org] [DOI] (I p)

José Manuel Pérez, Felipe A Arenas, Gonzalo A Pradenas, Juan M Sandoval, Claudio C Vásquez
Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes.
J Biol Chem: 2008, 283(12);7346-53
[PubMed:18211903] [WorldCat.org] [DOI] (P p)