Difference between revisions of "HemB"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28130 hemB]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28130 hemB]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=HemB HemB]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 36 kDa, 4.98   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 36 kDa, 4.98   

Revision as of 11:47, 8 April 2014

  • Description: porphobilinogen synthase

Gene name hemB
Synonyms
Essential no
Product porphobilinogen synthase
Function heme biosynthesis
Gene expression levels in SubtiExpress: hemB
Metabolic function and regulation of this protein in SubtiPathways:
HemB
MW, pI 36 kDa, 4.98
Gene length, protein length 972 bp, 324 aa
Immediate neighbours hemL, hemD
Sequences Protein DNA DNA_with_flanks
Genetic context
HemB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HemB expression.png
























Categories containing this gene/protein

biosynthesis of cofactors, phosphoproteins

This gene is a member of the following regulons

PerR regulon

The gene

Basic information

  • Locus tag: BSU28130

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2 5-aminolevulinate = porphobilinogen + 2 H2O (according to Swiss-Prot)
  • Protein family: ALADH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • phosphorylated on Arg-217 PubMed
  • Cofactor(s): zinc
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References