RpsR

• Description: ribosomal protein
  
  

Gene name	rpsR
Synonyms
Essential	yes PubMed
Product	ribosomal protein S18
Function	translation
Gene expression levels in SubtiExpress: rpsR
Interactions involving this protein in SubtInteract: RpsR
MW, pI	8 kDa, 11.494
Gene length, protein length	237 bp, 79 aa
Immediate neighbours	exoA, ssbA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation, essential genes

This gene is a member of the following regulons

ComK regulon, stringent response

The gene

Basic information

• Locus tag: BSU40890

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU40890

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ribosomal protein S18P family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • RpsF-RpsR, the heterodimer binds the structure in the rpsF mRNA 5' UTR PubMed

• Localization:

Database entries

• BsubCyc: BSU40890

• Structure:

• UniProt: P21475

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • yyaF-rpsF-ssbA-rpsR PubMed
  • rpsF-ssbA-rpsR PubMed

• Expression browser: rpsR PubMed

• Sigma factor:
  • rpsF: SigA PubMed

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed
  • ComK: transcription activation PubMed

• Regulatory mechanism:

• Additional information:
  • the mRNA is very stable (half-life > 15 min) PubMed
  • the mRNA contains a structured motif in the 5' UTR upstream of the rpsF ORF that is bound by RpsF-RpsR heterodimers and may be implicated in autogenous regulation PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: