Difference between revisions of "ThiE"

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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU38290&redirect=T BSU38290]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ywbI-thiME.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ywbI-thiME.html]
Line 91: Line 92:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU38290&redirect=T BSU38290]
  
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1G6C 1G6C]
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1G6C 1G6C]

Revision as of 15:08, 2 April 2014

  • Description: thiamine-phosphate pyrophosphorylase

Gene name thiE
Synonyms thiC, ipa-26d, ywbK
Essential no
Product thiamine-phosphate pyrophosphorylase
Function biosynthesis of thiamine
by 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate
to yield thiamine phosphate
Gene expression levels in SubtiExpress: thiE
Metabolic function and regulation of this protein in SubtiPathways:
thiE
MW, pI 23 kDa, 5.058
Gene length, protein length 666 bp, 222 aa
Immediate neighbours efeU, thiM
Sequences Protein DNA DNA_with_flanks
Genetic context
ThiE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ThiE expression.png















Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU38290

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate (according to Swiss-Prot)
  • Protein family: TMP-PPase family (according to Swiss-Prot)
  • Paralogous protein(s): TenI

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications