FtsY

• Description: signal recognition particle
  
  

Gene name	ftsY
Synonyms	srb
Essential	no
Product	signal recognition particle
Function	protein secretion
Gene expression levels in SubtiExpress: ftsY
Interactions involving this protein in SubtInteract: FtsY
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	36 kDa, 5.081
Gene length, protein length	987 bp, 329 aa
Immediate neighbours	smc, sivC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, sporulation proteins, membrane proteins

This gene is a member of the following regulons

GerE regulon, SigK regulon

The gene

Basic information

• Locus tag: BSU15950

Database entries

• BsubCyc: BSU15950

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: GTP-binding SRP family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • Ffh-FtsY in the signal recognition particle PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU15950

• Structure:
  • 2XXA (complex Ffh-FtsY-Scr RNA, from E. coli) PubMed

• UniProt: P51835

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rnc-smc-ftsY PubMed
  • ftsY PubMed

• Expression browser: ftsY PubMed

• Sigma factor:
  • rnc: SigA PubMed
  • ftsY: SigK PubMed

• Regulation:
  • expressed during vegetative growth and during sporulation in the mother cell (SigK, GerE) PubMed

• Regulatory mechanism:
  • GerE: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ottilie von Loeffelholz, Kèvin Knoops, Aileen Ariosa, Xin Zhang, Manikandan Karuppasamy, Karine Huard, Guy Schoehn, Imre Berger, Shu-ou Shan, Christiane Schaffitzel
Structural basis of signal sequence surveillance and selection by the SRP-FtsY complex.
Nat Struct Mol Biol: 2013, 20(5);604-10
[PubMed:23563142] [WorldCat.org] [DOI] (I p)

Sandro F Ataide, Nikolaus Schmitz, Kuang Shen, Ailong Ke, Shu-ou Shan, Jennifer A Doudna, Nenad Ban
The crystal structure of the signal recognition particle in complex with its receptor.
Science: 2011, 331(6019);881-6
[PubMed:21330537] [WorldCat.org] [DOI] (I p)

Geeske Zanen, Haike Antelmann, Rob Meima, Jan D H Jongbloed, Marc Kolkman, Michael Hecker, Jan Maarten van Dijl, Wim J Quax
Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis.
Proteomics: 2006, 6(12);3636-48
[PubMed:16705751] [WorldCat.org] [DOI] (P p)

Aileen Rubio, Xin Jiang, Kit Pogliano
Localization of translocation complex components in Bacillus subtilis: enrichment of the signal recognition particle receptor at early sporulation septa.
J Bacteriol: 2005, 187(14);5000-2
[PubMed:15995216] [WorldCat.org] [DOI] (P p)

Hiroshi Kakeshita, Akihiro Oguro, Reiko Amikura, Kouji Nakamura, Kunio Yamane
Expression of the ftsY gene, encoding a homologue of the alpha subunit of mammalian signal recognition particle receptor, is controlled by different promoters in vegetative and sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2000, 146 ( Pt 10);2595-2603
[PubMed:11021934] [WorldCat.org] [DOI] (P p)