NtdA

• Description: pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase
  
  

Gene name	ntdA
Synonyms	yhjL
Essential	no
Product	pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase
Function	synthesis of the antibiotic kanosamine
Gene expression levels in SubtiExpress: ntdA
MW, pI	49 kDa, 5.971
Gene length, protein length	1323 bp, 441 aa
Immediate neighbours	ntdB, ntdR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

NtdR regulon

The gene

Basic information

• Locus tag: BSU10550

Database entries

• BsubCyc: BSU10550

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • 3-oxo-d-glucose-6-phosphate + glutamate --> kanosamine-6-phosphate PubMed

• Protein family: degT/dnrJ/eryC1 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:
  • pyridoxalphosphate PubMed

• Effectors of protein activity:

• Interactions:
  • forms dimers PubMed

• Localization:

Database entries

• BsubCyc: BSU10550

• Structure:
  • 4K2I PubMed

• UniProt: O07566

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ntdA-ntdB-ntdC-glcP PubMed

• Expression browser: ntdA PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by 3,3'-neotrehalosadiamine (NtdR) PubMed

• Regulatory mechanism: NtdR: positive regulator PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Takashi Inaoka, Kozo Ochi
Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis.
Biosci Biotechnol Biochem: 2011, 75(4);618-23
[PubMed:21512256] [WorldCat.org] [DOI] (I p)