Difference between revisions of "Smc"
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| − | * '''Description:''' | + | * '''Description:''' part of the [[condensin]] complex, chromosomal origin condensation and segregation SMC protein <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || chromosome condensation and segregation SMC protein | |style="background:#ABCDEF;" align="center"| '''Product''' || chromosome condensation and segregation SMC protein | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || segregation of replication origins |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940 smc] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940 smc] | ||
| Line 57: | Line 57: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | + | * essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | |
| − | essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | + | * ''[[smc]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth {{PubMed|24440399,24440393}} |
=== Database entries === | === Database entries === | ||
| Line 82: | Line 82: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** part of the [[condensin]] complex {{PubMed|24440399,24440393}} | ||
** forms dimers {{PubMed|22385855}} | ** forms dimers {{PubMed|22385855}} | ||
** [[ScpA]]-[[Smc]] {{PubMed|12100548}} | ** [[ScpA]]-[[Smc]] {{PubMed|12100548}} | ||
| Line 98: | Line 99: | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
** nucleoid (heterogeneous) {{PubMed|16479537}} | ** nucleoid (heterogeneous) {{PubMed|16479537}} | ||
| − | ** the ([[Smc]])2-[[ScpA]]-[[ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half {{PubMed|23475963}} | + | ** the [[condensin]] ([[Smc]])2-[[ScpA]]-[[ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [[Spo0J]] {{PubMed|24440393,23475963}} |
=== Database entries === | === Database entries === | ||
| Line 151: | Line 152: | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 22385855 23475963</pubmed> | + | <pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 22385855 24440399,24440393 23475963</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:28, 16 February 2014
- Description: part of the condensin complex, chromosomal origin condensation and segregation SMC protein
| Gene name | smc |
| Synonyms | ylqA |
| Essential | yes PubMed |
| Product | chromosome condensation and segregation SMC protein |
| Function | segregation of replication origins |
| Gene expression levels in SubtiExpress: smc | |
| Interactions involving this protein in SubtInteract: Smc | |
| Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
| MW, pI | 135 kDa, 5.266 |
| Gene length, protein length | 3558 bp, 1186 aa |
| Immediate neighbours | rnc, ftsY |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA condensation/ segregation, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU15940
Phenotypes of a mutant
- essential PubMed
- smc mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: SMC family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P51834
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Rodrigo Reyes-Lamothe, Emilien Nicolas, David J Sherratt
Chromosome replication and segregation in bacteria.
Annu Rev Genet: 2012, 46;121-43
[PubMed:22934648]
[WorldCat.org]
[DOI]
(I p)
Justin S Lenhart, Jeremy W Schroeder, Brian W Walsh, Lyle A Simmons
DNA repair and genome maintenance in Bacillus subtilis.
Microbiol Mol Biol Rev: 2012, 76(3);530-64
[PubMed:22933559]
[WorldCat.org]
[DOI]
(I p)
Christine Kaimer, Peter L Graumann
Players between the worlds: multifunctional DNA translocases.
Curr Opin Microbiol: 2011, 14(6);719-25
[PubMed:22047950]
[WorldCat.org]
[DOI]
(I p)
Peter L Graumann, Tobias Knust
Dynamics of the bacterial SMC complex and SMC-like proteins involved in DNA repair.
Chromosome Res: 2009, 17(2);265-75
[PubMed:19308706]
[WorldCat.org]
[DOI]
(I p)
Original publications
