Difference between revisions of "GabR"
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' N-terminal DNA-binding helix-turn-helix motif | + | * '''[[Domains]]:''' |
| + | ** N-terminal DNA-binding helix-turn-helix motif (corresponding to domains of the [[GntR family]]) {{PubMed|24127574}} | ||
| + | ** C-terminal domain is homologous to PLP-binding large domain of aminotransferases {{PubMed|24127574}} | ||
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' gamma-aminobutyric acid, PLP {{PubMed|24127574}} |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 91: | Line 93: | ||
=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=4MGR 4MGR] {{PubMed|24127574}} | + | * '''Structure:''' |
| + | ** [http://www.rcsb.org/pdb/explore/explore.do?structureId=4MGR 4MGR] (the apo-protein) {{PubMed|24127574}} | ||
| + | ** [http://www.rcsb.org/pdb/explore/explore.do?structureId=4N0B 4N0B] (the complex with PLP) {{PubMed|24127574}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/P94426 P94426] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P94426 P94426] | ||
Revision as of 19:36, 21 December 2013
- Description: transcription activator of gabT-gabD, repressor of gabR (MocR/ GabR family)
| Gene name | gabR |
| Synonyms | ycnF |
| Essential | no |
| Product | transcription regulator |
| Function | regulation of gamma-amino butyric acid utilization |
| Gene expression levels in SubtiExpress: gabR | |
| MW, pI | 54 kDa, 6.709 |
| Gene length, protein length | 1437 bp, 479 aa |
| Immediate neighbours | yczG, gabT |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
utilization of amino acids, transcription factors and their control
This gene is a member of the following regulons
The GabR regulon:
The gene
Basic information
- Locus tag: BSU03890
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: MocR/ GabR family PubMed
- Paralogous protein(s): none, but there are 7 members of the MocR/ GabR family in B. subtilis
Extended information on the protein
- Kinetic information:
- Domains:
- N-terminal DNA-binding helix-turn-helix motif (corresponding to domains of the GntR family) PubMed
- C-terminal domain is homologous to PLP-binding large domain of aminotransferases PubMed
- Modification:
- Effectors of protein activity:
Database entries
- UniProt: P94426
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- GabR: negative autoregulation PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Linc Sonenshein, Tufts University, Boston, MA, USA Homepage
Your additional remarks
References
