Difference between revisions of "BrxB"
| Line 4: | Line 4: | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| − | |'' | + | |''brxB'' |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqiW '' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
| Line 71: | Line 71: | ||
* '''Protein family:''' UPF0403 family (according to Swiss-Prot) | * '''Protein family:''' UPF0403 family (according to Swiss-Prot) | ||
| − | * '''Paralogous protein(s):''' [[ | + | * '''Paralogous protein(s):''' [[BrxA]] |
=== Extended information on the protein === | === Extended information on the protein === | ||
| Line 77: | Line 77: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' contains an CxC redox motif redox active Cys residue [http://www.ncbi.nlm.nih.gov/pubmed/20308541] | + | * '''[[Domains]]:''' contains an CxC redox motif redox active Cys residue [http://www.ncbi.nlm.nih.gov/pubmed/20308541] |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 103: | Line 103: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' '' | + | * '''Operon:''' ''brxB'' (according to [http://dbtbs.hgc.jp/COG/prom/yqiW.html DBTBS]) |
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqiW_2493064_2493501_-1 yqiW] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqiW_2493064_2493501_-1 yqiW] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 132: | Line 132: | ||
=Your additional remarks= | =Your additional remarks= | ||
| − | [[YpdA]], [[ | + | [[YpdA]], [[BrxA]], [[BrxB]] and [[YtxJ]] cooccur in those species predicted to synthesize bacillithiol. |
=References= | =References= | ||
| − | <pubmed> 20308541</pubmed> | + | <pubmed> 24313874 20308541</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:50, 13 December 2013
- Description: bacilliredoxin
| Gene name | brxB |
| Synonyms | yqiW |
| Essential | no |
| Product | bacilliredoxin |
| Function | de-bacillithiolation of S-bacillithiolated OhrR and MetE |
| Gene expression levels in SubtiExpress: yqiW | |
| MW, pI | 16 kDa, 4.814 |
| Gene length, protein length | 435 bp, 145 aa |
| Immediate neighbours | artP, bmrU |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
membrane proteins, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU23990
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UPF0403 family (according to Swiss-Prot)
- Paralogous protein(s): BrxA
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P54534
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Operon: brxB (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
YpdA, BrxA, BrxB and YtxJ cooccur in those species predicted to synthesize bacillithiol.
References
Ahmed Gaballa, Bui Khanh Chi, Alexandra A Roberts, Dörte Becher, Chris J Hamilton, Haike Antelmann, John D Helmann
Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE.
Antioxid Redox Signal: 2014, 21(3);357-67
[PubMed:24313874]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541]
[WorldCat.org]
[DOI]
(I p)
