Difference between revisions of "ComP"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * the mutation suppresses the mucoid phenotype of ''[[motA]]'' or ''[[motB]]'' mutants due to loss of [[DegU]] phosphorylation and concomitant reduced expression of the ''[[pgsB]]-[[pgsC]]-[[pgsA]]'' operon {{PubMed|24296669}} | ||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' eight transmembrane segments | + | * '''[[Domains]]:''' eight transmembrane segments |
* '''Modification:''' autophosphorylation on a His residue | * '''Modification:''' autophosphorylation on a His residue | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' [[ComX]] (extracellular) | * '''Effectors of protein activity:''' [[ComX]] (extracellular) | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comP_3253529_3255838_-1 comP] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comP_3253529_3255838_-1 comP] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
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<pubmed>12576575 </pubmed> | <pubmed>12576575 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>11133937,8643670,12067344,10094672,10419951,2116363,9274030 18763711 | + | <pubmed>11133937,8643670,12067344,10094672,10419951,2116363,9274030 18763711 24296669 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:05, 4 December 2013
- Description: two-component sensor kinase, detects extracellular ComX
| Gene name | comP |
| Synonyms | |
| Essential | no |
| Product | two-component sensor kinase |
| Function | regulation of genetic competence and quorum sensing |
| Gene expression levels in SubtiExpress: comP | |
| Interactions involving this protein in SubtInteract: ComP | |
| MW, pI | 89 kDa, 7.997 |
| Gene length, protein length | 2307 bp, 769 aa |
| Immediate neighbours | comA, comX |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
genetic competence, protein modification, transcription factors and their control, quorum sensing, membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31690
Phenotypes of a mutant
- the mutation suppresses the mucoid phenotype of motA or motB mutants due to loss of DegU phosphorylation and concomitant reduced expression of the pgsB-pgsC-pgsA operon PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of ComA
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: eight transmembrane segments
- Modification: autophosphorylation on a His residue
- Effectors of protein activity: ComX (extracellular)
- Localization: cell membrane PubMed
Database entries
- Structure:
- UniProt: Q99027
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: comP PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575]
[WorldCat.org]
[DOI]
(P p)
Original Publications
