NiaP

• Description: nicotinate transporter
  
  

Gene name	yceI
Synonyms
Essential	no
Product	nicotinate transporter
Function	uptake of niacin
Gene expression levels in SubtiExpress: niaP
MW, pI	43 kDa, 9.502
Gene length, protein length	1200 bp, 400 aa
Immediate neighbours	yceH, yceJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

NadR regulon

The gene

Basic information

• Locus tag: BSU02950

Phenotypes of a mutant

• more sensitive to nisin PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: MFS transporter PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: 10 membrane-spanning domains PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: O34691

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: niaP PubMed

• Sigma factor:

• Regulation:
  • repressed in the presence of nicotinic acid (NadR) PubMed

• Regulatory mechanism:
  • NadR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Linda Jeanguenin, Aurora Lara-Núñez, Dmitry A Rodionov, Andrei L Osterman, Nataliya Y Komarova, Doris Rentsch, Jesse F Gregory, Andrew D Hanson
Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals.
Funct Integr Genomics: 2012, 12(1);25-34
[PubMed:21953179] [WorldCat.org] [DOI] (I p)

Original publications

Anthony W Kingston, Xiaojie Liao, John D Helmann
Contributions of the σ(W) , σ(M) and σ(X) regulons to the lantibiotic resistome of Bacillus subtilis.
Mol Microbiol: 2013, 90(3);502-18
[PubMed:23980836] [WorldCat.org] [DOI] (I p)

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Dmitry A Rodionov, Xiaoqing Li, Irina A Rodionova, Chen Yang, Leonardo Sorci, Etienne Dervyn, Dariusz Martynowski, Hong Zhang, Mikhail S Gelfand, Andrei L Osterman
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Nucleic Acids Res: 2008, 36(6);2032-46
[PubMed:18276644] [WorldCat.org] [DOI] (I p)