Difference between revisions of "UppS"
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
* essential {{PubMed|22904278}} | * essential {{PubMed|22904278}} | ||
− | * the ''[[uppS86]]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin {{PubMed|22904278}}=== Database entries === | + | * the ''[[uppS86]]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin {{PubMed|22904278}} |
+ | |||
+ | === Database entries === | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
Line 133: | Line 135: | ||
=References= | =References= | ||
− | <pubmed> 22904278 </pubmed> | + | <pubmed> 22904278 23796923 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 09:04, 1 July 2013
- Description: undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis
Gene name | uppS |
Synonyms | yluA |
Essential | yes PubMed |
Product | undecaprenyl pyrophosphate synthetase |
Function | cell wall biosynthesis |
Gene expression levels in SubtiExpress: uppS | |
MW, pI | 29 kDa, 5.408 |
Gene length, protein length | 780 bp, 260 aa |
Immediate neighbours | frr, cdsA |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of lipids, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16530
Phenotypes of a mutant
- essential PubMed
- the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
- Protein family: UPP synthetase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O31751
- KEGG entry: [2]
- E.C. number: 2.5.1.31
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Yong Heon Lee, John D Helmann
Reducing the Level of Undecaprenyl Pyrophosphate Synthase Has Complex Effects on Susceptibility to Cell Wall Antibiotics.
Antimicrob Agents Chemother: 2013, 57(9);4267-4275
[PubMed:23796923]
[WorldCat.org]
[DOI]
(I p)
Takashi Inaoka, Kozo Ochi
Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements.
J Bacteriol: 2012, 194(20);5632-7
[PubMed:22904278]
[WorldCat.org]
[DOI]
(I p)