ArsR

• Description: arsenic resistance operon repressor
  
  

Gene name	arsR
Synonyms	yqcJ
Essential	no
Product	transcription repressor
Function	regulation of as (III) efflux
Gene expression levels in SubtiExpress: arsR
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	12 kDa, 4.883
Gene length, protein length	315 bp, 105 aa
Immediate neighbours	yqcK, yqcI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against toxic metals, Skin element

This gene is a member of the following regulons

ArsR regulon, SigF regulon

The ArsR regulon

• arsR-yqcK-arsB-arsC

The gene

Basic information

• Locus tag: BSU25810

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P45949

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: arsR-yqcK-arsB-arsC PubMed

• Expression browser: arsR PubMed

• Sigma factor: SigA PubMed, SigF PubMed

• Regulation:
  • expressed early during sporulation in the forespore (SigF) PubMed
  • expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) (ArsR) PubMed

• Regulatory mechanism:
  • ArsR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)

T Sato, Y Kobayashi
The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite.
J Bacteriol: 1998, 180(7);1655-61
[PubMed:9537360] [WorldCat.org] [DOI] (P p)