HisJ

• Description: histidinol phosphate phosphatase
  
  

Gene name	hisJ
Synonyms	ytvP
Essential	no
Product	histidinol phosphate phosphatase
Function	biosynthesis of histidine
Gene expression levels in SubtiExpress: hisJ
Metabolic function and regulation of this protein in SubtiPathways: His
MW, pI	30 kDa, 5.061
Gene length, protein length	804 bp, 268 aa
Immediate neighbours	ezrA, refZ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The gene

Basic information

• Locus tag: BSU29620

Phenotypes of a mutant

auxotroph for histidine

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-histidinol phosphate + H₂O = L-histidinol + phosphate (according to Swiss-Prot)

• Protein family: HisK subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34411

• KEGG entry: [2]

• E.C. number: 3.1.3.15

Expression and regulation

• Operon:

• Expression browser: hisJ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France

References

D le Coq, S Fillinger, S Aymerich
Histidinol phosphate phosphatase, catalyzing the penultimate step of the histidine biosynthesis pathway, is encoded by ytvP (hisJ) in Bacillus subtilis.
J Bacteriol: 1999, 181(10);3277-80
[PubMed:10322033] [WorldCat.org] [DOI] (P p)