PenP

• Description: beta-lactamase
  
  

Gene name	penP
Synonyms
Essential	no
Product	beta-lactamase
Function	resistance to beta-lactam antibiotics
Gene expression levels in SubtiExpress: penP
MW, pI	33 kDa, 9.208
Gene length, protein length	918 bp, 306 aa
Immediate neighbours	yoaZ, yobA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against toxins/ antibiotics

The gene

Basic information

• Locus tag: BSU18800

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: A beta-lactam + H₂O = a substituted beta-amino acid (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • extracellular (signal peptide) PubMed

Database entries

• Structure: 3KGM (from B. licheniformis, 58% identity, 79% similarity)

• UniProt: P39824

• KEGG entry: [2]

• E.C. number: 3.5.2.6

Expression and regulation

• Operon:

• Expression browser: penP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Birgit Voigt, Haike Antelmann, Dirk Albrecht, Armin Ehrenreich, Karl-Heinz Maurer, Stefan Evers, Gerhard Gottschalk, Jan Maarten van Dijl, Thomas Schweder, Michael Hecker
Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis.
J Mol Microbiol Biotechnol: 2009, 16(1-2);53-68
[PubMed:18957862] [WorldCat.org] [DOI] (I p)