Difference between revisions of "Mta"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of multidrug-efflux transporter genes | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of multidrug-efflux transporter genes | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36600 mta] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 4.949 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 4.949 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[clsA]]'', ''[[ywnC]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[clsA]]'', ''[[ywnC]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU36600 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU36600 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU36600 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:mta_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:mta_context.gif]] | ||
Revision as of 14:04, 13 May 2013
- Description: transcriptional activator of multidrug-efflux transporter genes, activates ymfD expression
| Gene name | mta |
| Synonyms | ywnD |
| Essential | no |
| Product | transcriptional activator |
| Function | regulation of multidrug-efflux transporter genes |
| Gene expression levels in SubtiExpress: mta | |
| MW, pI | 29 kDa, 4.949 |
| Gene length, protein length | 771 bp, 257 aa |
| Immediate neighbours | clsA, ywnC |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transcription factors and their control, resistance against toxins/ antibiotics
This gene is a member of the following regulons
The Mta regulon
The gene
Basic information
- Locus tag: BSU36600
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P71039
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: mta PubMed
- Regulation:
- positive autoregulation PubMed
- Regulatory mechanism:
- Mta: transcription activation PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Mohamed Marahiel, Marburg University, Germany homepage
Richard Brennan, Houston, Texas, USA Homepage
Your additional remarks
References
Marcus Miethke, Sarah Schmidt, Mohamed A Marahiel
The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis.
J Bacteriol: 2008, 190(15);5143-52
[PubMed:18502870]
[WorldCat.org]
[DOI]
(I p)
Kate J Newberry, Richard G Brennan
The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.
J Biol Chem: 2004, 279(19);20356-62
[PubMed:14985361]
[WorldCat.org]
[DOI]
(P p)
M H Godsey, N N Baranova, A A Neyfakh, R G Brennan
Crystal structure of MtaN, a global multidrug transporter gene activator.
J Biol Chem: 2001, 276(50);47178-84
[PubMed:11581256]
[WorldCat.org]
[DOI]
(P p)
M H Godsey, N N Baranova, A A Neyfakh, R G Brennan
Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis.
Acta Crystallogr D Biol Crystallogr: 2000, 56(Pt 11);1456-8
[PubMed:11053850]
[WorldCat.org]
[DOI]
(P p)
N N Baranova, A Danchin, A A Neyfakh
Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters.
Mol Microbiol: 1999, 31(5);1549-59
[PubMed:10200972]
[WorldCat.org]
[DOI]
(P p)
E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933]
[WorldCat.org]
[DOI]
(P p)
