Difference between revisions of "NiaP"

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|style="background:#ABCDEF;" align="center"|'''Function''' || uptake of niacin
 
|style="background:#ABCDEF;" align="center"|'''Function''' || uptake of niacin
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU02950 niaP]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU02950 niaP]
 
|-
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 43 kDa, 9.502   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 43 kDa, 9.502   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yceH]]'', ''[[yceJ]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yceH]]'', ''[[yceJ]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12089&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU02950 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU02950 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU02950 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:yceI_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yceI_context.gif]]

Revision as of 12:05, 13 May 2013

  • Description: nicotinate transporter

Gene name yceI
Synonyms
Essential no
Product nicotinate transporter
Function uptake of niacin
Gene expression levels in SubtiExpress: niaP
MW, pI 43 kDa, 9.502
Gene length, protein length 1200 bp, 400 aa
Immediate neighbours yceH, yceJ
Sequences Protein DNA Advanced_DNA
Genetic context
YceI context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NiaP expression.png
























Categories containing this gene/protein

transporters/ other, biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

NadR regulon

The gene

Basic information

  • Locus tag: BSU02950

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: MFS transporter PubMed
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: 10 membrane-spanning domains PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
    • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Linda Jeanguenin, Aurora Lara-Núñez, Dmitry A Rodionov, Andrei L Osterman, Nataliya Y Komarova, Doris Rentsch, Jesse F Gregory, Andrew D Hanson
Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals.
Funct Integr Genomics: 2012, 12(1);25-34
[PubMed:21953179] [WorldCat.org] [DOI] (I p)

Original publications

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Dmitry A Rodionov, Xiaoqing Li, Irina A Rodionova, Chen Yang, Leonardo Sorci, Etienne Dervyn, Dariusz Martynowski, Hong Zhang, Mikhail S Gelfand, Andrei L Osterman
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Nucleic Acids Res: 2008, 36(6);2032-46
[PubMed:18276644] [WorldCat.org] [DOI] (I p)