Difference between revisions of "Adk"
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|style="background:#ABCDEF;" align="center"|'''Function''' || ADP formation | |style="background:#ABCDEF;" align="center"|'''Function''' || ADP formation | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU01370 adk] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]''' | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[secY]]'', ''[[map]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[secY]]'', ''[[map]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU01370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU01370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU01370 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:adk_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:adk_context.gif]] | ||
Revision as of 11:59, 13 May 2013
- Description: adenylate kinase
| Gene name | adk |
| Synonyms | |
| Essential | yes PubMed |
| Product | adenylate kinase |
| Function | ADP formation |
| Gene expression levels in SubtiExpress: adk | |
| Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Nucleotides (regulation), Protein secretion | |
| MW, pI | 23 kDa, 4.449 |
| Gene length, protein length | 651 bp, 217 aa |
| Immediate neighbours | secY, map |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01370
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + AMP = 2 ADP (according to Swiss-Prot)
- Protein family: adenylate kinase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1P3J
- UniProt: P16304
- KEGG entry: [2]
- E.C. number: 2.7.4.3 2.7.4.3]
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Thomas H Segall-Shapiro, Peter Q Nguyen, Edgardo D Dos Santos, Saurav Subedi, Justin Judd, Junghae Suh, Jonathan J Silberg
Mesophilic and hyperthermophilic adenylate kinases differ in their tolerance to random fragmentation.
J Mol Biol: 2011, 406(1);135-48
[PubMed:21145325]
[WorldCat.org]
[DOI]
(I p)
Rafael Couñago, Corey J Wilson, Matthew I Peña, Pernilla Wittung-Stafshede, Yousif Shamoo
An adaptive mutation in adenylate kinase that increases organismal fitness is linked to stability-activity trade-offs.
Protein Eng Des Sel: 2008, 21(1);19-27
[PubMed:18093993]
[WorldCat.org]
[DOI]
(P p)
J W Suh, S A Boylan, S H Oh, C W Price
Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region.
Gene: 1996, 169(1);17-23
[PubMed:8635744]
[WorldCat.org]
[DOI]
(P p)
