SecY

• Description: preprotein translocase subunit, universally conserved protein
  
  

Gene name	secY
Synonyms
Essential	yes PubMed
Product	preprotein translocase subunit
Function	protein secretion
Gene expression levels in SubtiExpress: secY
Interactions involving this protein in SubtInteract: SecY
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	47 kDa, 10.209
Gene length, protein length	1293 bp, 431 aa
Immediate neighbours	rplO, adk
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, essential genes, membrane proteins, universally conserved proteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU01360

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: secY/SEC61-alpha family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (SecY-SecE-SecG)2-SecA2 PubMed
  • FloT-SecY PubMed

• Localization: membrane PubMed

Database entries

• Structure: 3DL8 (structure of the (SecY-SecE-SecG)-SecA complex PubMed

• UniProt: P16336

• KEGG entry: [2]

• E.C. number:

Additional information

universally conserved protein

Expression and regulation

• Operon: rplO-secY-adk-map

• Expression browser: secY PubMed

• Sigma factor:

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant: Pspac-secY PubMed

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Juri Niño Bach, Marc Bramkamp
Flotillins functionally organize the bacterial membrane.
Mol Microbiol: 2013, 88(6);1205-17
[PubMed:23651456] [WorldCat.org] [DOI] (I p)

Jochen Zimmer, Yunsun Nam, Tom A Rapoport
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature: 2008, 455(7215);936-43
[PubMed:18923516] [WorldCat.org] [DOI] (I p)

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

John F Hunt, Sevil Weinkauf, Lisa Henry, John J Fak, Paul McNicholas, Donald B Oliver, Johann Deisenhofer
Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA.
Science: 2002, 297(5589);2018-26
[PubMed:12242434] [WorldCat.org] [DOI] (I p)

J W Suh, S A Boylan, S H Oh, C W Price
Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region.
Gene: 1996, 169(1);17-23
[PubMed:8635744] [WorldCat.org] [DOI] (P p)

R Breitling, B Schlott, D Behnke
Modulation of the spc operon affects growth and protein secretion in Bacillus subtilis.
J Basic Microbiol: 1994, 34(3);145-55
[PubMed:8071801] [WorldCat.org] [DOI] (P p)

J W Suh, S A Boylan, S M Thomas, K M Dolan, D B Oliver, C W Price
Isolation of a secY homologue from Bacillus subtilis: evidence for a common protein export pathway in eubacteria.
Mol Microbiol: 1990, 4(2);305-14
[PubMed:2110998] [WorldCat.org] [DOI] (P p)