Difference between revisions of "RecX"

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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[DNA repair/recombination]]}}
+
{{SubtiWiki category|[[DNA repair/ recombination]]}}
  
 
= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
 +
* reduced natural tranformation with plasmid or chromosomal DNA {{PubMed|23284295}}
  
 
=== Database entries ===
 
=== Database entries ===
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=== Additional information===
 
=== Additional information===
 
 
  
  
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
 
+
** modulates the "length or packing" of a [[RecA]] filament, thereby [[RecX]] facilitates the initiation of recombination and increases recombination across species {{PubMed|23284295}}
 
* '''Protein family:''' recX family (according to Swiss-Prot)
 
* '''Protein family:''' recX family (according to Swiss-Prot)
  
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* '''[[Localization]]:'''
 
* '''[[Localization]]:'''
** cytoplasm (according to Swiss-Prot)
+
** forms foci on the nucleoid upon DNA damage {{PubMed|23284295}}
 +
** forms foci at the cells poles and/ or the nucleoid upon induction of genetic competence {{PubMed|23284295}}
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 13:17, 4 January 2013

  • Description: recombination protein, modulates the SOS response and facilitates RecA-mediated recombinational repair and genetic recombination

Gene name recX
Synonyms yfhG
Essential no
Product recombination protein
Function DNA repair/recombination
Gene expression levels in SubtiExpress: recX
MW, pI 30 kDa, 6.292
Gene length, protein length 792 bp, 264 aa
Immediate neighbours yfhF, yfhH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YfhG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YfhG expression.png















Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU08520

Phenotypes of a mutant

  • reduced natural tranformation with plasmid or chromosomal DNA PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • modulates the "length or packing" of a RecA filament, thereby RecX facilitates the initiation of recombination and increases recombination across species PubMed
  • Protein family: recX family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • forms foci on the nucleoid upon DNA damage PubMed
    • forms foci at the cells poles and/ or the nucleoid upon induction of genetic competence PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Paula P Cárdenas, Begoña Carrasco, Clarisse Defeu Soufo, Carolina E César, Katharina Herr, Miriam Kaufenstein, Peter L Graumann, Juan C Alonso
RecX facilitates homologous recombination by modulating RecA activities.
PLoS Genet: 2012, 8(12);e1003126
[PubMed:23284295] [WorldCat.org] [DOI] (I p)

Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849] [WorldCat.org] [DOI] (I p)