Difference between revisions of "PolC"
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=== Additional information=== | === Additional information=== | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot) | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot) | ||
| + | ** required for bacteriophage SPP1 replication {{PubMed|23268446}} | ||
* '''Protein family:''' PolC subfamily (according to Swiss-Prot) | * '''Protein family:''' PolC subfamily (according to Swiss-Prot) | ||
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=References= | =References= | ||
| − | '''Additional publications:''' {{PubMed|21740522,21958350}} | + | '''Additional publications:''' {{PubMed|23268446,21740522,21958350}} |
<pubmed>15186423, 20122408,11721055</pubmed> | <pubmed>15186423, 20122408,11721055</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:07, 2 January 2013
- Description: DNA polymerase III (alpha subunit), part of the replisome
| Gene name | polC |
| Synonyms | mutI, dnaF, dnaP |
| Essential | yes PubMed |
| Product | DNA polymerase III (alpha subunit) |
| Function | DNA replication |
| Gene expression levels in SubtiExpress: polC | |
| Interactions involving this protein in SubtInteract: PolC | |
| MW, pI | 162 kDa, 5.135 |
| Gene length, protein length | 4311 bp, 1437 aa |
| Immediate neighbours | proS, ylxS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16580
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
- required for bacteriophage SPP1 replication PubMed
- Protein family: PolC subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- forms foci PubMed
- cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P13267
- KEGG entry: [2]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
