TatCD

• Description: component of the TatAdCd twin-arginine translocase
  
  

Gene name	tatCD
Synonyms	ycbT
Essential	no
Product	component of the twin-arginine translocation pathway
Function	TAT protein secretion
Gene expression levels in SubtiExpress: tatCD
Interactions involving this protein in SubtInteract: TatCD
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	27 kDa, 9.342
Gene length, protein length	735 bp, 245 aa
Immediate neighbours	tatAD, pcp
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphate metabolism, protein secretion, membrane proteins

This gene is a member of the following regulons

PhoP regulon

The gene

Basic information

• Locus tag: BSU02640

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: translocation of PhoD PubMed

• Protein family: tatC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • TatAD-TatCD PubMed
  • TatAC-TatCD PubMed
  • CsbC-TatCD PubMed

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: P42252

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: phoD-tatAD-tatCD PubMed

• Expression browser: tatCD PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions of phosphate limitation (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Oscar Kuipers, University of Groningen, The Netherlands Homepage

References

Reviews

Tracy Palmer, Ben C Berks
The twin-arginine translocation (Tat) protein export pathway.
Nat Rev Microbiol: 2012, 10(7);483-96
[PubMed:22683878] [WorldCat.org] [DOI] (I e)