Difference between revisions of "FolK"
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* '''Operon:''' ''[[pabB]]-[[pabA]]-[[pabC]]-[[sul]]-[[folB]]-[[folK]]-[[yazB]]-[[yacF]]-[[lysS]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] | * '''Operon:''' ''[[pabB]]-[[pabA]]-[[pabC]]-[[sul]]-[[folB]]-[[folK]]-[[yazB]]-[[yacF]]-[[lysS]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] | ||
| − | * '''[ | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=folK_86946_87449_1 folK] {{PubMed|22383849}} |
| + | |||
| + | * '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] | ||
* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 14:04, 7 August 2012
- Description: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
| Gene name | folK |
| Synonyms | |
| Essential | no |
| Product | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase |
| Function | biosynthesis of folate |
| Metabolic function and regulation of this protein in SubtiPathways: Folate | |
| MW, pI | 18 kDa, 4.531 |
| Gene length, protein length | 501 bp, 167 aa |
| Immediate neighbours | folB, yazB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00790
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate (according to Swiss-Prot)
- Protein family: HPPK family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- UniProt: P29252
- KEGG entry: [3]
- E.C. number: 2.7.6.3
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
