PyrH

• Description: uridylate kinase
  
  

Gene name	pyrH
Synonyms	smbA
Essential	no
Product	uridylate kinase
Function	pyrimidine biosynthesis
Gene expression levels in SubtiExpress: pyrH
Metabolic function and regulation of this protein in SubtiPathways: Pyrimidines, Nucleotides (regulation)
MW, pI	25 kDa, 5.101
Gene length, protein length	720 bp, 240 aa
Immediate neighbours	tsf, frr
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU16510

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + UMP = ADP + UDP (according to Swiss-Prot)

• Protein family: UMP kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 2JJX (from Bacillus anthracis, 42% identity, 64% similarity) PubMed

• UniProt: O31749

• KEGG entry: [2]

• E.C. number: 2.7.4.22

Expression and regulation

• Operon:

• Expression browser: pyrH PubMed

• Sigma factor:

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: