Difference between revisions of "YabA"

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m (Reverted edits by 134.76.70.252 (talk) to last revision by Jstuelk)
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* '''Description:''' tethers [[DnaA]] to the polymerase-clamp protein [[DnaN]] <br/><br/>
  
 
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|style="background:#ABCDEF;" align="center"|'''Function''' || positioning of [[DnaA]]
 
|style="background:#ABCDEF;" align="center"|'''Function''' || positioning of [[DnaA]]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU00330 yabA]
 
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YabA YabA]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YabA YabA]
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|colspan="2" | '''Genetic context''' <br/> [[Image:yabA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yabA_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yabA_42499_42858_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:yabA_expression.png|500px]]
 
 
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* '''Operon:'''  
 
* '''Operon:'''  
  
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yabA_42499_42858_1 yabA] {{PubMed|22383849}}
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* '''[[Sigma factor]]:'''  
 
 
* '''Sigma factor:'''  
 
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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* '''Regulatory mechanism:'''  
 
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* '''Additional information:'''  
  
 
=Biological materials =
 
=Biological materials =

Revision as of 09:27, 7 August 2012

  • Description: tethers DnaA to the polymerase-clamp protein DnaN

Gene name yabA
Synonyms
Essential no
Product negative regulator of replication initiation
Function positioning of DnaA
Interactions involving this protein in SubtInteract: YabA
MW, pI 13 kDa, 6.065
Gene length, protein length 357 bp, 119 aa
Immediate neighbours yaaT, yabB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YabA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA replication

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU00330

Phenotypes of a mutant

strongly reduced growth rate in minimal medium PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • negative control of replication initiation PubMed
    • associates with the oriC region in a DnaA-dependent manner, this limits the amount of DnaA that can bind the oriC region PubMed
    • YabA inhibits co-operative DNA binding by DnaA PubMed
  • Protein family: yabA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: leucine zipper
  • Modification:
  • Cofactor(s): Zn cluster
  • Effectors of protein activity:
    • DnaN overexpression or release from the replisome decreases association of YabA with oriC, increases association of DnaA with oriC PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Philippe Noirot, Jouy-en-Josas, France Homepage
Alan Grossman, Cambridge, MA, USA Homepage

Your additional remarks

References

Reviews

Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337] [WorldCat.org] [DOI] (I p)

Original publications