AppD

Gene name	appD
Synonyms
Essential	no
Product	oligopeptide ABC transporter (ATP-binding protein))
Function	uptake of oligopeptides
Gene expression levels in SubtiExpress: appD
Interactions involving this protein in SubtInteract: AppD
Metabolic function and regulation of this protein in SubtiPathways: Alternative nitrogen sources
MW, pI	36 kDa, 5.388
Gene length, protein length	984 bp, 328 aa
Immediate neighbours	yjaZ, appF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, utilization of nitrogen sources other than amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon, ScoC regulon

The gene

Basic information

• Locus tag: BSU11360

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transporter domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (AppD-AppF)-(AppB-AppC)-AppA PubMed

• Localization: attached to the cell membrane (via AppB-AppC) PubMed

Database entries

• Structure:

• UniProt: P42064

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: appD-appF-appA-appB-appC PubMed

• Expression browser: appD PubMed

• Sigma factor:

• Regulation:
  • repressed by CodY PubMed
  • repressed during exponential growth (ScoC) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed1 PubMed2
  • ScoC: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: