Difference between revisions of "Metabolism of signalling nucleotides"
| Line 26: | Line 26: | ||
* [[GdpP]] | * [[GdpP]] | ||
| − | ===c-di-GMP degradation=== | + | ===c-di-GMP degradation (presence of an EAL domain)=== |
| + | * [[YkoW]] | ||
* [[YkuI]] | * [[YkuI]] | ||
| + | * [[YuxH]] | ||
| − | ===c-di-GMP synthesis | + | === c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)=== |
| + | * [[GdpP]] | ||
| + | * [[YdaK]] | ||
* [[YhcK]] | * [[YhcK]] | ||
* [[YkoW]] | * [[YkoW]] | ||
* [[YtrP]] (this enzyme may be inactive due to the lack of important residues) | * [[YtrP]] (this enzyme may be inactive due to the lack of important residues) | ||
| + | |||
| + | === Targets of signalling nucleotides === | ||
| + | * ppGpp targets | ||
| + | ** GdpP | ||
| + | |||
| + | * c-di-GMP targets | ||
| + | ** YpfA (contains a PilZ domain) | ||
==Important original publications== | ==Important original publications== | ||
Revision as of 11:59, 24 July 2012
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Contents
Genes in this functional category
ppGpp synthesis and degradation
c-di-AMP synthesis
c-di-AMP degradation
c-di-GMP degradation (presence of an EAL domain)
c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)
Targets of signalling nucleotides
- ppGpp targets
- GdpP
- c-di-GMP targets
- YpfA (contains a PilZ domain)
Important original publications
Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650]
[WorldCat.org]
[DOI]
(I p)
Important reviews
Mark Gomelsky
cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!
Mol Microbiol: 2011, 79(3);562-5
[PubMed:21255104]
[WorldCat.org]
[DOI]
(I p)
Tilman Schirmer, Urs Jenal
Structural and mechanistic determinants of c-di-GMP signalling.
Nat Rev Microbiol: 2009, 7(10);724-35
[PubMed:19756011]
[WorldCat.org]
[DOI]
(I p)
Regine Hengge
Principles of c-di-GMP signalling in bacteria.
Nat Rev Microbiol: 2009, 7(4);263-73
[PubMed:19287449]
[WorldCat.org]
[DOI]
(I p)
Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086]
[WorldCat.org]
[DOI]
(I e)
Peggy A Cotter, Scott Stibitz
c-di-GMP-mediated regulation of virulence and biofilm formation.
Curr Opin Microbiol: 2007, 10(1);17-23
[PubMed:17208514]
[WorldCat.org]
[DOI]
(P p)
Ute Römling, Mark Gomelsky, Michael Y Galperin
C-di-GMP: the dawning of a novel bacterial signalling system.
Mol Microbiol: 2005, 57(3);629-39
[PubMed:16045609]
[WorldCat.org]
[DOI]
(P p)
