Difference between revisions of "DnaD"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
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** [[DnaD]]-[[DnaB]] {{PubMed|15186423,19707554}} | ** [[DnaD]]-[[DnaB]] {{PubMed|15186423,19707554}} | ||
** part of the [[replisome]]: [[PolC]]-[[HolA]]-[[HolB]]-[[DnaX]]-[[DnaN]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[SsbA]]-[[DnaE]]-[[PriA]]-[[DnaB]] {{PubMed|20122408}} | ** part of the [[replisome]]: [[PolC]]-[[HolA]]-[[HolB]]-[[DnaX]]-[[DnaN]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[SsbA]]-[[DnaE]]-[[PriA]]-[[DnaB]] {{PubMed|20122408}} | ||
| + | ** part of the [[primosome]]: [[DnaA]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[DnaB]] {{PubMed|22797751}} | ||
* '''[[Localization]]:''' Membrane-proximal (Spotty) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed] | * '''[[Localization]]:''' Membrane-proximal (Spotty) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed] | ||
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* '''Regulation:''' | * '''Regulation:''' | ||
** constitutively expressed {{PubMed|21954439}} | ** constitutively expressed {{PubMed|21954439}} | ||
| + | ** there are about 3,000 to 5,000 molecules of [[DnaD]] per cell {{PubMed|15686560}} | ||
** expression is transiently increased after treatment with H2O2 {{PubMed|21954439}} | ** expression is transiently increased after treatment with H2O2 {{PubMed|21954439}} | ||
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=References= | =References= | ||
| − | + | ==Reviews== | |
| + | <pubmed> 22797751</pubmed> | ||
| + | ==Original publications== | ||
<pubmed> 19707554,15686560,15186423,11585815, 20122408,16479537, 11222620 19968790 11679082 20587500 21097613 21954439</pubmed> | <pubmed> 19707554,15686560,15186423,11585815, 20122408,16479537, 11222620 19968790 11679082 20587500 21097613 21954439</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:26, 17 July 2012
- Description: initiation of chromosome replication, part of the replisome
| Gene name | dnaD |
| Synonyms | |
| Essential | yes PubMed |
| Product | initiation of chromosome replication |
| Function | DNA replication |
| Interactions involving this protein in SubtInteract: DnaD | |
| MW, pI | 27 kDa, 7.174 |
| Gene length, protein length | 696 bp, 232 aa |
| Immediate neighbours | nth, asnS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22350
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: DNA polymerase type-Y family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: Membrane-proximal (Spotty) PubMed
Database entries
- Structure: 2C79 (N-terminal domain)
- UniProt: P39787
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
Operon: dnaD-nth PubMed
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Geoffrey S Briggs, Wiep Klaas Smits, Panos Soultanas
Chromosomal replication initiation machinery of low-G+C-content Firmicutes.
J Bacteriol: 2012, 194(19);5162-70
[PubMed:22797751]
[WorldCat.org]
[DOI]
(I p)
Original publications
