Difference between revisions of "FadB"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
− | {{SubtiWiki category|[[utilization of lipids]]}} | + | {{SubtiWiki category|[[utilization of lipids]]}}, |
+ | {{SubtiWiki category|[[phosphoproteins]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = |
Revision as of 15:16, 20 April 2012
- Description: 3-hydroxyacyl-CoA dehydratase
Gene name | fadB |
Synonyms | ysiB |
Essential | no |
Product | 3-hydroxyacyl-CoA dehydratase |
Function | fatty acid degradation |
Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation | |
MW, pI | 27 kDa, 4.951 |
Gene length, protein length | 774 bp, 258 aa |
Immediate neighbours | etfB, fadR |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
utilization of lipids, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28540
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O (according to Swiss-Prot)
- Protein family: enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 3PEA (from B. anthracis, 49% identity, 66% similarity)
- UniProt: P94549
- KEGG entry: [3]
- E.C. number: 4.2.1.17
Additional information
Expression and regulation
- Regulation:
- induced by long-chain fatty acids (FadR) PubMed
- subject to carbon catabolite repression (3.8-fold) (CcpA-HPr(Ser-P) PubMed
- Regulatory mechanism:
- FadR: transcription repression PubMed
- CcpA-HPr(Ser-P): transcription repression PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287]
[WorldCat.org]
[DOI]
(P p)
Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250]
[WorldCat.org]
[DOI]
(P p)
Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135]
[WorldCat.org]
[DOI]
(P p)