Difference between revisions of "HxlR"
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification | + | * '''Catalyzed reaction/ biological activity:''' transcription activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification |
* '''Protein family:''' [[MarR/DUF24 family]] | * '''Protein family:''' [[MarR/DUF24 family]] | ||
Revision as of 14:01, 20 April 2012
- Description: MarR/DUF24 family transcription activator of the hxlA-hxlB operon
| Gene name | hxlR |
| Synonyms | yckH |
| Essential | no |
| Product | MarR/DUF24 family transcription activator |
| Function | regulation of the ribulose monophosphate pathway |
| MW, pI | 14 kDa, 6.358 |
| Gene length, protein length | 360 bp, 120 aa |
| Immediate neighbours | hxlA, srfAA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
transcription factors and their control, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The HxlR regulon:
The gene
Basic information
- Locus tag: BSU03470
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification
- Protein family: MarR/DUF24 family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: formaldehyde stimulates transcription activation by HxlR
Database entries
- Structure:
- UniProt: P42406
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: hxlR (according to DBTBS)
- Sigma factor:
- Regulation:
- Regulatory mechanism:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796]
[WorldCat.org]
[DOI]
(I p)
Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879]
[WorldCat.org]
[DOI]
(I p)
Nobuo Kato, Hiroya Yurimoto, Rudolf K Thauer
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem: 2006, 70(1);10-21
[PubMed:16428816]
[WorldCat.org]
[DOI]
(P p)
H Yasueda, Y Kawahara, S Sugimoto
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
J Bacteriol: 1999, 181(23);7154-60
[PubMed:10572115]
[WorldCat.org]
[DOI]
(P p)
