YclM

• Description: aspartokinase III
  
  

Gene name	yclM
Synonyms
Essential	no
Product	aspartokinase III
Function	unknown
Metabolic function and regulation of this protein in SubtiPathways: Lys, Thr
MW, pI	49 kDa, 4.783
Gene length, protein length	1362 bp, 454 aa
Immediate neighbours	yczN, yclN
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The gene

Basic information

• Locus tag: BSU03790

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + L-aspartate = ADP + 4-phospho-L-aspartate (according to Swiss-Prot)

• Protein family: aspartokinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: inhibited by the simultaneous presence of threonine and lysine PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94417

• KEGG entry: [3]

• E.C. number: 2.7.2.4

Expression and regulation

• Operon: yclM (according to DBTBS)

• Expression browser: yclM PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Chien-Chi Lo, Carol A Bonner, Gary Xie, Mark D'Souza, Roy A Jensen
Cohesion group approach for evolutionary analysis of aspartokinase, an enzyme that feeds a branched network of many biochemical pathways.
Microbiol Mol Biol Rev: 2009, 73(4);594-651
[PubMed:19946135] [WorldCat.org] [DOI] (I p)