Difference between revisions of "NatR"
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* '''Effectors of protein activity:''' phosphorylation likely affects DNA-binding activity | * '''Effectors of protein activity:''' phosphorylation likely affects DNA-binding activity | ||
| − | * '''Interactions:''' [[NatK]]-[[NatR]] | + | * '''[[SubtInteract|Interactions]]:''' |
| + | ** [[NatK]]-[[NatR]] | ||
| − | * '''Localization:''' cytoplasm (according to Swiss-Prot) | + | * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot) |
=== Database entries === | === Database entries === | ||
Revision as of 17:33, 5 December 2011
- Description: two-component response regulator, regulation of the natA-natB operon
| Gene name | natR |
| Synonyms | yccH |
| Essential | no |
| Product | two-component response regulator |
| Function | regulation of the natA-natB operon |
| Interactions involving this protein in SubtInteract: NatR | |
| MW, pI | 26 kDa, 6.614 |
| Gene length, protein length | 699 bp, 233 aa |
| Immediate neighbours | natK, natA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
metal ion homeostasis (K, Na, Ca, Mg), transcription factors and their control, phosphoproteins
This gene is a member of the following regulons
The NatR regulon:
The gene
Basic information
- Locus tag: BSU02740
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: OmpR family of two-component response regulators
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated by NatK on an Asp residue
- Cofactor(s):
- Effectors of protein activity: phosphorylation likely affects DNA-binding activity
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P70955
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: natR (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Mitsuo Ogura, Kensuke Tsukahara, Kentaro Hayashi, Teruo Tanaka
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Microbiology (Reading): 2007, 153(Pt 3);667-675
[PubMed:17322186]
[WorldCat.org]
[DOI]
(P p)
C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672]
[WorldCat.org]
[DOI]
(P p)
