Difference between revisions of "SpoIIR"
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=== Additional information=== | === Additional information=== | ||
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| − | |||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' interacts with and activates the pro-[[SigE]] protease [[SpoIIGA]] in the intermembrane space between the forespore and the mother cell {{PubMed|22111992}} |
* '''Protein family:''' | * '''Protein family:''' | ||
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* '''Modification:''' | * '''Modification:''' | ||
| + | ** likely acylated on Thr-27 {{PubMed|22111992}} | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** [[SpoIIR]]-[[SpoIIGA]] {{PubMed|22111992}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
| − | ** localizes initially to the forespore septal membrane, is then exported to the intermembrane space between the forespore and the mother cell | + | ** localizes initially to the forespore septal membrane (in a [[SpoIIGA]]-dependent manner), is then exported to the intermembrane space between the forespore and the mother cell {{PubMed|22111992}} |
=== Database entries === | === Database entries === | ||
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=References= | =References= | ||
| − | + | '''Additional publications:''' {{PubMed|22111992}} | |
| − | <pubmed>16497325,7585939,15044948,11849534, 19578359 20802044 | + | <pubmed>16497325,7585939,15044948,11849534, 19578359 20802044 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:25, 25 November 2011
- Description: required for processing and compartmentalization of pro-SigE
| Gene name | spoIIR |
| Synonyms | ipc-27d, csfX |
| Essential | no |
| Product | morphological chekcpoint for SigE processing |
| Function | control of SigE activation |
| MW, pI | 25 kDa, 4.737 |
| Gene length, protein length | 672 bp, 224 aa |
| Immediate neighbours | ywlB, ywlA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
sigma factors and their control, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU36970
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: interacts with and activates the pro-SigE protease SpoIIGA in the intermembrane space between the forespore and the mother cell PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- likely acylated on Thr-27 PubMed
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P39151
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: spoIIR (according to DBTBS)
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Vasant K Chary, Panagiotis Xenopoulos, Avigdor Eldar, Patrick J Piggot
Loss of compartmentalization of σ(E) activity need not prevent formation of spores by Bacillus subtilis.
J Bacteriol: 2010, 192(21);5616-24
[PubMed:20802044]
[WorldCat.org]
[DOI]
(I p)
Avigdor Eldar, Vasant K Chary, Panagiotis Xenopoulos, Michelle E Fontes, Oliver C Losón, Jonathan Dworkin, Patrick J Piggot, Michael B Elowitz
Partial penetrance facilitates developmental evolution in bacteria.
Nature: 2009, 460(7254);510-4
[PubMed:19578359]
[WorldCat.org]
[DOI]
(I p)
Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325]
[WorldCat.org]
[DOI]
(P p)
Aileen Rubio, Kit Pogliano
Septal localization of forespore membrane proteins during engulfment in Bacillus subtilis.
EMBO J: 2004, 23(7);1636-46
[PubMed:15044948]
[WorldCat.org]
[DOI]
(P p)
Masaya Fujita, Richard Losick
An investigation into the compartmentalization of the sporulation transcription factor sigmaE in Bacillus subtilis.
Mol Microbiol: 2002, 43(1);27-38
[PubMed:11849534]
[WorldCat.org]
[DOI]
(P p)
A E Hofmeister, A Londoño-Vallejo, E Harry, P Stragier, R Losick
Extracellular signal protein triggering the proteolytic activation of a developmental transcription factor in B. subtilis.
Cell: 1995, 83(2);219-26
[PubMed:7585939]
[WorldCat.org]
[DOI]
(P p)
