Difference between revisions of "TopA"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| + | ** TopA interacts with the [[RNA polymerase]] {{PubMed|21710567}} | ||
* '''Localization:''' | * '''Localization:''' | ||
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=References= | =References= | ||
| − | + | '''Additional publications:''' {{PubMed|21710567}} | |
<pubmed>17114254, </pubmed> | <pubmed>17114254, </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:50, 29 June 2011
- Description: DNA topoisomerase I
| Gene name | topA |
| Synonyms | topI |
| Essential | no |
| Product | DNA topoisomerase I |
| Function | replication |
| MW, pI | 78 kDa, 9.023 |
| Gene length, protein length | 2073 bp, 691 aa |
| Immediate neighbours | dprA, trmFO |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16120
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining (according to Swiss-Prot)
- Protein family: prokaryotic type I/III topoisomerase family (according to Swiss-Prot)
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- TopA interacts with the RNA polymerase PubMed
- Localization:
Database entries
- Structure:
- UniProt: P39814
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: topA (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
