Difference between revisions of "Maf"
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=== Additional information=== | === Additional information=== | ||
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* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| − | * '''Regulation:''' | + | * '''Regulation:''' |
| + | ** expressed when cells enter the compentent state ([[ComK]]) {{PubMed|11948146}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[ComK]]: transcription activation {{PubMed|21564336}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
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==Original publications== | ==Original publications== | ||
| − | <pubmed> 21564336 10841541 8387996</pubmed> | + | <pubmed> 21564336 10841541 8387996 11948146 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 07:23, 23 May 2011
- Description: cell division inhibitor in competent cells
| Gene name | maf |
| Synonyms | |
| Essential | no |
| Product | cell division inhibitor |
| Function | cell division control |
| MW, pI | 21 kDa, 5.711 |
| Gene length, protein length | 567 bp, 189 aa |
| Immediate neighbours | radC, spoIIB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28050
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: maf family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): binds phosphorylated compounds (UTP, IMP, IDP, GDP and others) in in vitro experiments
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure: 1EX2
- UniProt: Q02169
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original publications
Kenneth Briley, Peter Prepiak, Miguel J Dias, Jeanette Hahn, David Dubnau
Maf acts downstream of ComGA to arrest cell division in competent cells of B. subtilis.
Mol Microbiol: 2011, 81(1);23-39
[PubMed:21564336]
[WorldCat.org]
[DOI]
(I p)
Mitsuo Ogura, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.
J Bacteriol: 2002, 184(9);2344-51
[PubMed:11948146]
[WorldCat.org]
[DOI]
(P p)
G Minasov, M Teplova, G C Stewart, E V Koonin, W F Anderson, M Egli
Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proc Natl Acad Sci U S A: 2000, 97(12);6328-33
[PubMed:10841541]
[WorldCat.org]
[DOI]
(P p)
Y X Butler, Y Abhayawardhane, G C Stewart
Amplification of the Bacillus subtilis maf gene results in arrested septum formation.
J Bacteriol: 1993, 175(10);3139-45
[PubMed:8387996]
[WorldCat.org]
[DOI]
(P p)
