FtsH

• Description: ATP-dependent metalloprotease
  
  

Gene name	ftsH
Synonyms
Essential	no
Product	ATP-dependent metalloprotease
Function	cell division, sporulation initiation
Metabolic function and regulation of this protein in SubtiPathways: Phosphorelay, Stress
MW, pI	70 kDa, 5.841
Gene length, protein length	1911 bp, 637 aa
Immediate neighbours	hprT, coaX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell division, cell envelope stress proteins (controlled by SigM, W, X, Y), heat shock proteins, membrane proteins

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

• Locus tag: BSU00690

Phenotypes of a mutant

strongly reduced sporulation frequency

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: degrades Spo0E, resulting in reduced sporulation frequency in a ftsH mutant

• Protein family:

• Paralogous protein(s): YjoB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot), membrane PubMed

Database entries

• Structure: 1LV7 (from E. coli, 64% identity) PubMed

• UniProt: P37476

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • ftsH PubMed
  • tilS-hprT-ftsH PubMed

• Sigma factor: SigA PubMed, SigM PubMed

• Regulation: induced by heat shock (class III)

• Regulatory mechanism:

• Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: