Phosphorelay

Parent categories	4. Lifestyles 4.2. Sporulation and Germination
Neighbouring categories	4.2.1. Sporulation proteins 4.2.2. Phosphorelay 4.2.3. Sporulation/ other 4.2.4. Germination
Related categories	two-component systems response regulator aspartate phosphatases phosphoproteins protein kinases and phosphatases
Overview on the categories (Excel file) All genes and their categories (Excel file)

Parent categories	3. Information processing 3.4. Regulation of gene expression
Neighbouring categories	3.4.1. Sigma factors and their control 3.4.2. Transcription factors and their control 3.4.3. Trigger enzymes 3.4.4. RNA binding regulators 3.4.5. Regulators of core metabolism 3.4.6. Transition state regulators 3.4.7. Phosphorelay 3.4.8. Quorum sensing
Related categories	see Table to the right
Overview on the categories (Excel file) All genes and their categories (Excel file)

The phosphorelay is a complex variation of a two-component regulatory system. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems.

The kinases

• KinA (controlled by Sda, KipI, and KipA)
• KinB (controlled by Sda, KbaA, and KapB)
• KinC
• KinD
• KinE

The phosphotransferases

• Spo0F
• Spo0B

The ultimate target

• Spo0A

Phosphatases controlling the phosphorelay (and peptides that modulate their activity)

• Spo0E: dephosphorylation of Spo0A
• YisI: dephosphorylation of Spo0A
• YnzD: dephosphorylation of Spo0A
• RapA, PhrA: dephosphorylation of Spo0F
• RapB: dephosphorylation of Spo0F
• RapE, PhrE: dephosphorylation of Spo0F
• RapH: dephosphorylation of Spo0F

A mathematical model

Sara Jabbari, John T Heap, John R King
Mathematical modelling of the sporulation-initiation network in Bacillus subtilis revealing the dual role of the putative quorum-sensing signal molecule PhrA.
Bull Math Biol: 2011, 73(1);181-211
[PubMed:20238180] [WorldCat.org] [DOI] (I p)

Reviews

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Peter Dürre
Ancestral sporulation initiation.
Mol Microbiol: 2011, 80(3);584-7
[PubMed:21435030] [WorldCat.org] [DOI] (I p)

Imke G de Jong, Jan-Willem Veening, Oscar P Kuipers
Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.
J Bacteriol: 2010, 192(8);2053-67
[PubMed:20154131] [WorldCat.org] [DOI] (I p)

Ruth E Silversmith
Auxiliary phosphatases in two-component signal transduction.
Curr Opin Microbiol: 2010, 13(2);177-83
[PubMed:20133180] [WorldCat.org] [DOI] (I p)

Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980] [WorldCat.org] [DOI] (I p)

Daelynn R Buelow, Tracy L Raivio
Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases.
Mol Microbiol: 2010, 75(3);547-66
[PubMed:19943903] [WorldCat.org] [DOI] (I p)

J A Hoch
The phosphorelay signal transduction pathway in the initiation of Bacillus subtilis sporulation.
J Cell Biochem: 1993, 51(1);55-61
[PubMed:8432743] [WorldCat.org] [DOI] (P p)

Important original publications

Anna L McLoon, Ilana Kolodkin-Gal, Shmuel M Rubinstein, Roberto Kolter, Richard Losick
Spatial regulation of histidine kinases governing biofilm formation in Bacillus subtilis.
J Bacteriol: 2011, 193(3);679-85
[PubMed:21097618] [WorldCat.org] [DOI] (I p)