CzcD

• Description: cation diffusion facilitator
  
  

Gene name	czcD
Synonyms	yrdO
Essential	no
Product	cation diffusion facilitator
Function	cation efflux, resistence against Zn, Cu, Co, Ni
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	34 kDa, 5.859
Gene length, protein length	933 bp, 311 aa
Immediate neighbours	trkA, yrdN
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), resistance against toxic metals, membrane proteins

This gene is a member of the following regulons

CzrA regulon

The gene

Basic information

• Locus tag: BSU26650

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O07084

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: czcD-trkA PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) (CzrA) PubMed

• Regulatory mechanism:
  • CzrA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)