Difference between revisions of "MrpA"
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| − | * '''Description:''' Na+/H+ antiporter | + | * '''Description:''' Na+ transporter subunit of the Na+/H+ antiporter, multiple resistance and pH homeostasis <br/><br/> |
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' Na+ transporter subunit of the Na+/H+ antiporter {{PubMed|21236240}} |
* '''Protein family:''' | * '''Protein family:''' | ||
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=References= | =References= | ||
| − | <pubmed>15019740,11004162,17693497 ,10198001, 19389778 16730649 </pubmed> | + | <pubmed>15019740,11004162,17693497 ,10198001, 19389778 16730649 21236240</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:01, 18 January 2011
- Description: Na+ transporter subunit of the Na+/H+ antiporter, multiple resistance and pH homeostasis
| Gene name | mrpA |
| Synonyms | yufT, shaA, ntrA |
| Essential | yes PubMed |
| Product | Na+/H+ antiporter subunit |
| Function | sodium export |
| MW, pI | 86 kDa, 9.519 |
| Gene length, protein length | 2322 bp, 774 aa |
| Immediate neighbours | yufS, mrpB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), essential genes, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31600
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Na+ transporter subunit of the Na+/H+ antiporter PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: Q9K2S2
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Vamsi K Moparthi, Brijesh Kumar, Cecilie Mathiesen, Cecilia Hägerhäll
Homologous protein subunits from Escherichia coli NADH:quinone oxidoreductase can functionally replace MrpA and MrpD in Bacillus subtilis.
Biochim Biophys Acta: 2011, 1807(4);427-36
[PubMed:21236240]
[WorldCat.org]
[DOI]
(P p)
Yusuke Kajiyama, Masato Otagiri, Junichi Sekiguchi, Toshiaki Kudo, Saori Kosono
The MrpA, MrpB and MrpD subunits of the Mrp antiporter complex in Bacillus subtilis contain membrane-embedded and essential acidic residues.
Microbiology (Reading): 2009, 155(Pt 7);2137-2147
[PubMed:19389778]
[WorldCat.org]
[DOI]
(P p)
Yusuke Kajiyama, Masato Otagiri, Junichi Sekiguchi, Saori Kosono, Toshiaki Kudo
Complex formation by the mrpABCDEFG gene products, which constitute a principal Na+/H+ antiporter in Bacillus subtilis.
J Bacteriol: 2007, 189(20);7511-4
[PubMed:17693497]
[WorldCat.org]
[DOI]
(P p)
Saori Kosono, Yusuke Kajiyama, Shin Kawasaki, Toko Yoshinaka, Koki Haga, Toshiaki Kudo
Functional involvement of membrane-embedded and conserved acidic residues in the ShaA subunit of the multigene-encoded Na+/H+ antiporter in Bacillus subtilis.
Biochim Biophys Acta: 2006, 1758(5);627-35
[PubMed:16730649]
[WorldCat.org]
[DOI]
(P p)
Saori Kosono, Kei Asai, Yoshito Sadaie, Toshiaki Kudo
Altered gene expression in the transition phase by disruption of a Na+/H+ antiporter gene (shaA) in Bacillus subtilis.
FEMS Microbiol Lett: 2004, 232(1);93-9
[PubMed:15019740]
[WorldCat.org]
[DOI]
(P p)
M Ito, A A Guffanti, W Wang, T A Krulwich
Effects of nonpolar mutations in each of the seven Bacillus subtilis mrp genes suggest complex interactions among the gene products in support of Na(+) and alkali but not cholate resistance.
J Bacteriol: 2000, 182(20);5663-70
[PubMed:11004162]
[WorldCat.org]
[DOI]
(P p)
M Ito, A A Guffanti, B Oudega, T A Krulwich
mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.
J Bacteriol: 1999, 181(8);2394-402
[PubMed:10198001]
[WorldCat.org]
[DOI]
(P p)
