Difference between revisions of "Fur"
| Line 43: | Line 43: | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
{{SubtiWiki regulon|[[PerR regulon]]}} | {{SubtiWiki regulon|[[PerR regulon]]}} | ||
| − | + | =The [[Fur regulon]]= | |
=The gene= | =The gene= | ||
| Line 139: | Line 139: | ||
=References= | =References= | ||
| − | + | ==The [[Fur regulon]]== | |
| − | <pubmed>18487332 | + | <pubmed>12374814,12354229, </pubmed> |
| + | ==Other original publications== | ||
| + | <pubmed>18487332,14563870,18697947,10400588,11790741,16672620,12207695,9701813,12029044,,17725565,17012385,12950915,19508286 , 16672620, </pubmed> | ||
[http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed] | [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed] | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:11, 13 December 2010
- Description: transcription regulator of iron homoeostasis
| Gene name | fur |
| Synonyms | yqkL |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of iron homoeostasis
and transcription of ferri-siderophore uptake genes |
| Metabolic function and regulation of this protein in SubtiPathways: Alternative nitrogen sources, Protein secretion | |
| MW, pI | 17 kDa, 5.374 |
| Gene length, protein length | 447 bp, 149 aa |
| Immediate neighbours | ripX, spoIIM |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
acquisition of iron, iron metabolism, transcription factors and their control
This gene is a member of the following regulons
The Fur regulon
The gene
Basic information
- Locus tag: BSU23520
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Fur family (according to Swiss-Prot)
Genes controlled by Fur
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): contains an iron-sulfur cluster
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P54574
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: fur PubMed
- Additional information:
Biological materials
- Mutant: HB6543 (aphA3), available in the John Helmann lab; also available in the Stülke lab GP879 (fur::mls) and GP868 (fur::mls, perR::spc)
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
The Fur regulon
Noel Baichoo, John D Helmann
Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence.
J Bacteriol: 2002, 184(21);5826-32
[PubMed:12374814]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)
Other original publications
