Difference between revisions of "DesK"
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| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[lipid metabolism/ other]]}}, | ||
| + | {{SubtiWiki category|[[protein modification]]}}, | ||
| + | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
| + | {{SubtiWiki category|[[cold stress proteins]]}}, | ||
| + | {{SubtiWiki category|[[membrane proteins]]}}, | ||
| + | {{SubtiWiki category|[[phosphoproteins]]}} | ||
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| + | = This gene is a member of the following [[regulons]] = | ||
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=The gene= | =The gene= | ||
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=The protein= | =The protein= | ||
Revision as of 20:20, 8 December 2010
- Description: two-component sensor kinase, regulation of cold shock expression of des
| Gene name | desK |
| Synonyms | yocF |
| Essential | no |
| Product | two-component sensor kinase |
| Function | regulation of cold shock expression of des |
| Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation | |
| MW, pI | 42 kDa, 9.428 |
| Gene length, protein length | 1110 bp, 370 aa |
| Immediate neighbours | des, desR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
lipid metabolism/ other, protein modification, transcription factors and their control, cold stress proteins, membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU19190
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of DesR
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- 5 transmembrane helices
- cytoplasmatic C-terminal trail
- Modification: autophosphorylation on a His residue
- Cofactor(s):
- Effectors of protein activity: unsaturated fatty acids are negative effectors of the system
- Localization: membrane (transmembrane segments)
Database entries
- Structure: 3EHF
- UniProt: O34757
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- induced by cold shock (12-fold) PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Diego de Mendoza, Universidad Nacional de Rosario, Argentine homepage
- Mohamed Marahiel, Marburg University, Germany homepage
Your additional remarks
References
Reviews
Richard C Stewart
Protein histidine kinases: assembly of active sites and their regulation in signaling pathways.
Curr Opin Microbiol: 2010, 13(2);133-41
[PubMed:20117042]
[WorldCat.org]
[DOI]
(I p)
Pablo S Aguilar, Diego de Mendoza
Control of fatty acid desaturation: a mechanism conserved from bacteria to humans.
Mol Microbiol: 2006, 62(6);1507-14
[PubMed:17087771]
[WorldCat.org]
[DOI]
(P p)
Original publications
