Difference between revisions of "FosB"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, W, X, Y)]]}},
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{{SubtiWiki category|[[resistance against toxins/ antibiotics]]}}
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= This gene is a member of the following [[regulons]] =
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{{SubtiWiki regulon|[[SigW regulon]]}}
  
 
=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, W, X, Y)]]}},
 
{{SubtiWiki category|[[resistance against toxins/ antibiotics]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 20:03, 8 December 2010

  • Description: bacillithiol-S-transferase; confers resistence against antimicrobial compounds from B. amyloliquefaciens

Gene name fosB
Synonyms yndN
Essential no
Product fosfomycin resistance protein
Function confers resistence against antimicrobial compounds
from B. amyloliquefaciens
MW, pI 17 kDa, 6.137
Gene length, protein length 432 bp, 144 aa
Immediate neighbours yndM, lexA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YndN context.gif
This image was kindly provided by SubtiList




Categories containing this gene/protein

cell envelope stress proteins (controlled by SigM, W, X, Y), resistance against toxins/ antibiotics

This gene is a member of the following regulons

SigW regulon

The gene

Basic information

  • Locus tag: BSU17840

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: FosB subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

John D Helmann
Bacillithiol, a new player in bacterial redox homeostasis.
Antioxid Redox Signal: 2011, 15(1);123-33
[PubMed:20712413] [WorldCat.org] [DOI] (I p)

Bronwyn G Butcher, John D Helmann
Identification of Bacillus subtilis sigma-dependent genes that provide intrinsic resistance to antimicrobial compounds produced by Bacilli.
Mol Microbiol: 2006, 60(3);765-82
[PubMed:16629676] [WorldCat.org] [DOI] (P p)

M Cao, B A Bernat, Z Wang, R N Armstrong, J D Helmann
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
J Bacteriol: 2001, 183(7);2380-3
[PubMed:11244082] [WorldCat.org] [DOI] (P p)