Difference between revisions of "RecA"
| Line 30: | Line 30: | ||
<br/><br/><br/> | <br/><br/><br/> | ||
| + | |||
| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[DNA repair/ recombination]]}}, | ||
| + | {{SubtiWiki category|[[genetic competence]]}} | ||
| + | |||
| + | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[ComK regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[LexA regulon]]}} | ||
=The gene= | =The gene= | ||
| Line 49: | Line 57: | ||
| − | + | ||
| − | |||
| − | |||
=The protein= | =The protein= | ||
Revision as of 19:52, 8 December 2010
- Description: multifunctional protein involved in homologous recombination and DNA repair (LexA-autocleavage)
| Gene name | recA |
| Synonyms | recE |
| Essential | no |
| Product | multifunctional protein involved in homologous recombination and DNA repair (LexA-autocleavage) |
| Function | homologous recombination, DNA repair |
| MW, pI | 37 kDa, 4.883 |
| Gene length, protein length | 1041 bp, 347 aa |
| Immediate neighbours | cinA, pbpX |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
DNA repair/ recombination, genetic competence
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16940
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
RecA filaments are dismantled from DNA by PcrA PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: recA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated on Ser-2 PubMed
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot), Nucleoid (Mid-cell) PubMed
Database entries
- Structure:
- UniProt: P16971
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: recA PubMed
- Regulation:
- Additional information:
Biological materials
- Mutant: IRN444 (cat), available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Peter Graumann, Freiburg University, Germany homepage
Your additional remarks
References
Reviews
Justin Courcelle, Philip C Hanawalt
RecA-dependent recovery of arrested DNA replication forks.
Annu Rev Genet: 2003, 37;611-46
[PubMed:14616075]
[WorldCat.org]
[DOI]
(P p)
Michael M Cox
The bacterial RecA protein as a motor protein.
Annu Rev Microbiol: 2003, 57;551-77
[PubMed:14527291]
[WorldCat.org]
[DOI]
(P p)
Shelley L Lusetti, Michael M Cox
The bacterial RecA protein and the recombinational DNA repair of stalled replication forks.
Annu Rev Biochem: 2002, 71;71-100
[PubMed:12045091]
[WorldCat.org]
[DOI]
(P p)
M M Cox
Recombinational DNA repair in bacteria and the RecA protein.
Prog Nucleic Acid Res Mol Biol: 1999, 63;311-66
[PubMed:10506835]
[WorldCat.org]
[DOI]
(P p)
Original publications
