SteT

• Description: serine/ threonine exchanger transporter
  
  

Gene name	steT
Synonyms	ykbA
Essential	no
Product	serine/ threonine exchanger transporter
Function	exchange of serine and threonine
MW, pI	46 kDa, 9.184
Gene length, protein length	1314 bp, 438 aa
Immediate neighbours	ykaA, mhqA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU12860

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

transporters/ other, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: membrane

Database entries

• Structure:

• UniProt: O34739

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: steT

• Sigma factor:

• Regulation: expression activated by glucose (4.2 fold) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Christian A Bippes, Antra Zeltina, Fabio Casagrande, Merce Ratera, Manuel Palacin, Daniel J Muller, Dimitrios Fotiadis
Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter.
J Biol Chem: 2009, 284(28);18651-63
[PubMed:19419962] [WorldCat.org] [DOI] (P p)

Núria Reig, César del Rio, Fabio Casagrande, Mercè Ratera, Josep Lluís Gelpí, David Torrents, Peter J F Henderson, Hao Xie, Stephen A Baldwin, Antonio Zorzano, Dimitrios Fotiadis, Manuel Palacín
Functional and structural characterization of the first prokaryotic member of the L-amino acid transporter (LAT) family: a model for APC transporters.
J Biol Chem: 2007, 282(18);13270-81
[PubMed:17344220] [WorldCat.org] [DOI] (P p)

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)