AdhR

• Description: transcriptional activator of adhA-yraA
  
  

Gene name	adhR
Synonyms	yraB
Essential	no
Product	transcriptional activator (MerR family)
Function	regulation of the protective response to formaldehyde
MW, pI	16 kDa, 9.637
Gene length, protein length	420 bp, 140 aa
Immediate neighbours	yraD, adhA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU27000

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: activity probably controlled via thiol-(S)-alkylation in Cys-52 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: spore wall (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O06008

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)