Difference between revisions of "FosB"
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| − | * '''Description:''' bacillithiol-S-transferase; confers resistence against antimicrobial compounds from B. amyloliquefaciens <br/><br/> | + | * '''Description:''' bacillithiol-S-transferase; confers resistence against antimicrobial compounds from ''B. amyloliquefaciens'' <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || fosfomycin resistance protein | |style="background:#ABCDEF;" align="center"| '''Product''' || fosfomycin resistance protein | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || confers resistence against antimicrobial compounds <br/>from B. amyloliquefaciens | + | |style="background:#ABCDEF;" align="center"|'''Function''' || confers resistence against antimicrobial compounds <br/>from ''B. amyloliquefaciens'' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 6.137 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 6.137 | ||
| Line 119: | Line 119: | ||
=References= | =References= | ||
| − | <pubmed>11244082,16629676,, </pubmed> | + | <pubmed>11244082,16629676, 20712413, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:21, 18 August 2010
- Description: bacillithiol-S-transferase; confers resistence against antimicrobial compounds from B. amyloliquefaciens
| Gene name | fosB |
| Synonyms | yndN |
| Essential | no |
| Product | fosfomycin resistance protein |
| Function | confers resistence against antimicrobial compounds from B. amyloliquefaciens |
| MW, pI | 17 kDa, 6.137 |
| Gene length, protein length | 432 bp, 144 aa |
| Immediate neighbours | yndM, lexA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU17840
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: FosB subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O31817
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: fosB PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
John D Helmann
Bacillithiol, a new player in bacterial redox homeostasis.
Antioxid Redox Signal: 2011, 15(1);123-33
[PubMed:20712413]
[WorldCat.org]
[DOI]
(I p)
Bronwyn G Butcher, John D Helmann
Identification of Bacillus subtilis sigma-dependent genes that provide intrinsic resistance to antimicrobial compounds produced by Bacilli.
Mol Microbiol: 2006, 60(3);765-82
[PubMed:16629676]
[WorldCat.org]
[DOI]
(P p)
M Cao, B A Bernat, Z Wang, R N Armstrong, J D Helmann
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
J Bacteriol: 2001, 183(7);2380-3
[PubMed:11244082]
[WorldCat.org]
[DOI]
(P p)
