Difference between revisions of "YpbH"
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | + | deletion reduces sporulation to 20%, overexpression abolishes sporulation {{PubMed|11914365}} | |
=== Database entries === | === Database entries === | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[YpbH]]-[[ClpC]] | + | * '''Interactions:''' [[YpbH]]-[[ClpC]] {{PubMed|11914365}} |
* '''Localization:''' | * '''Localization:''' | ||
| Line 94: | Line 94: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** low expression, enhanced in stat phase in LB or competence but not in sporulation medium {{PubMed|11914365}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
Revision as of 19:14, 5 August 2010
- Description: putative adaptor protein
| Gene name | ypbH |
| Synonyms | |
| Essential | no |
| Product | putative adaptor protein |
| Function | unknown |
| MW, pI | 22 kDa, 4.095 |
| Gene length, protein length | 582 bp, 194 aa |
| Immediate neighbours | gudB, ypbG |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU22970
Phenotypes of a mutant
deletion reduces sporulation to 20%, overexpression abolishes sporulation PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): MecA
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: P50734
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- low expression, enhanced in stat phase in LB or competence but not in sporulation medium PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: BD3349 (spc) , available in the Kürsad Turgay lab, also available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
Feng Wang, Ziqing Mei, Yutao Qi, Chuangye Yan, Siheng Xiang, Zhiyuan Zhou, Qi Hu, Jiawei Wang, Yigong Shi
Crystal structure of the MecA degradation tag.
J Biol Chem: 2009, 284(49);34376-81
[PubMed:19801546]
[WorldCat.org]
[DOI]
(I p)
Marjan Persuh, Ines Mandic-Mulec, David Dubnau
A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.
J Bacteriol: 2002, 184(8);2310-3
[PubMed:11914365]
[WorldCat.org]
[DOI]
(P p)
