Difference between revisions of "TrpC"

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(Database entries)
(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
 
+
* '''Operon:'''  
* '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]-[[hisC]]-[[tyrA]]-[[aroE]]'' {{PubMed|3924737}}
+
** ''[[aroF]]-[[aroB]]-[[aroH]]-[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]-[[hisC]]-[[tyrA]]-[[aroE]]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])
 +
** ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]-[[hisC]]-[[tyrA]]-[[aroE]]'' {{PubMed|3924737}}
  
 
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|6436812}}
 
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|6436812}}

Revision as of 14:51, 1 August 2010

  • Description: indole-3-glycerol-phosphate synthase

Gene name trpC
Synonyms
Essential no
Product indole-3-glycerol-phosphate synthase
Function biosynthesis of tryptophan
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 27 kDa, 5.535
Gene length, protein length 750 bp, 250 aa
Immediate neighbours trpF, trpD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
TrpC context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU22660

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1VC4 (from Thermus thermophilus, 36% identity, 49% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:
    • TRAP: binding to the mRNA in the presence of tryptophan, this results in transcription termination PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References